ME APASIONA LA CIENCIA ACA VA MI CV:

CURRICULUM VITAE



PERSONAL INFORMATION

Name: Oscar Alfredo Brown

Place of birth: La Plata, Buenos Aires.

Date of birth: 07/15/62.

Marital status: single.

Nationality: Argentina.

Passport #: ---.

Home address: calle 120 # 1460, La Plata (1900), Buenos Aires, Argentina.
Phone: (54 2)---.

Actual position: Associate Researcher from National Research Council of Science and tecnology (CONICET), argentina.

Emails: ---.com.ar or ---.com.ar


EDUCATION

1981 Chemical Technologist. Albert Thomas National School. La Plata, Buenos
Aires, Argentina.

1988 BsC Chemistry. Faculty of Exact Sciences, National University of La Plata
(UNLP). La Plata, Buenos Aires, Argentina.

1990 MSc Biochemistry. Faculty of Exact Sciences, UNLP. La Plata, Buenos
Aires, Argentina.

1997 PhD. Faculty of Exact Sciences, UNLP. La Plata, Buenos Aires, Argentina.



POST-GRADUATE COURSES

1989 "Endocrinology '89: Clinical & laboratory test for the diagnosis of
endocrine pathology". Faculty of Exact Sciences, UNLP. Argentina.

1991 "Parasites and health". Children's Hospital of La Plata. Argentina.

1993 "Biological membranes: structure and molecular interactions". Faculty of
Medicine, UNLP. Argentina.

1993 "Experimental nuclear spectrometry". Faculty of Exact Sciences, UNLP.
Argentina.

1993 "Advanced enzymatic kinetics". Faculty of Biochemistry & Pharmacy,
University of Buenos Aires (UBA). Argentina.

1995 "Training in molecular neurobiology and gene therapy" Laboratory of
Molecular and Cellular Neurobiology, Physiology Unit, School of
Molecular and Medical Biosciences, University of Wales, College of
Cardiff, UK.

2004 ¨Molecular Biology¨, Laboratory fisiology with biofísics, ". Faculty of
Medicine, UNLP. Argentina.


2005 ¨ Metodology of Radioisótopes¨. ". Faculty of Biochemistry & Pharmacy, UBA. Such course let to obtain the Licency to work with radioactive material. The Licency give by the Nuclear Regulatory Autority (ARN).



TEACHING EXPERIENCE

1984 - 1989 Undergraduate Teaching Assistant. General Biology, Faculty of Exact
Sciences, UNLP. La Plata, Argentina.

1987 -1988 Teacher Substitute of Organic Chemistry I. Albert Thomas National
School. La Plata, Argentina.

1989 - 1990 Teaching Assistant. General Biology, Faculty of Exact Sciences, UNLP.

1990 - 1991 Instructor . General Biology, Faculty of Exact Sciences, UNLP.

1992-1995 Instructor . General Biology, Faculty of Exact Sciences, UNLP.

1996-2001 Chief of Practical Work. General Biology, Faculty of Exact Sciences,
UNLP.



AWARDS

1993 Biannual price of "The Biochemical Federation" for the research work presented
at Latin-American proceedings of Clinical Biochemistry by the work: "Thymic hormones as mediators of the immunogonadotropha integration" O.A. Brown, Y.E. Sosa, R.G. Goya Latin-American proceedings of Clinical Biochemistry 28: 203-209 (1994). ARG

2007 Price of ¨The Medical Asociation of Argentine-Argentine Society of Pharmacology and Terapeutics¨ for the research work presented in Argentine Society of Pharmacology and Terapeutics by the work: ¨Restoration of reproductive function in immunodeficient mice by the way of the use gene therapy with the gene of the thymulin peptide¨P.C. Reggiani, E.V. Martínes, G.A. Camihort, G. Luna, O.A. Brown, R.G.Goya, G.M.Cónsole Argentine Society of Pharmacology and Terapeutics 1(41): 1-6 (2007).ARG


GRANTS

ONE´S OWN:

1995 Research Grant from Sandoz Foundation for Gerontological Research , Basel,
Switzerland. Ref. No LA-94-2-01. Ammount awarded: US$ 8,000.

Grant from The Sir Halley Stewart Trust, Cambridge, U.K. Ammount awarded:
£ 2.000.

2002- Grant to O.A. Brown from the Fundación Antorchas., Buenos Aires, Argentina..
Ammount awarded: $ 24.200

2003- Grant to O.A. Brown from the Fundación Antorchas , Buenos Aires, Argentina.
Amount awarded: $ 24.200.

INSIDE THE RESPONSEBLE GROUP:

2004-2006 grant bianual co-financiado por el National Institute on Aging (NIA) y el Fogarty International Center (FIC), NIH, USA. Tema: Gene therapy in the aging brain and pituitary gland. Colaboradora estadounidense, Martha C. Bohn, Northwstern University, Chicago; (Código: # 1 R21 TW006665); Monto: US$ 250.400.

1992 - 1994 "Réseau Nord-Sud", subsidio bienal financiado por el INSERM de Francia. Programa científico bienal franco-argentino-brasilero. Monto: FF 300.000.
1992-1993 Research Grant otorgado por la SANDOZ Foundation for Gerontological Research, Basel, Switzerland

2004-2007 Subsidio trienal PICT05-38214,otorgado por la Agencia Nacional de Promoción Científica y Tecnológica. Tema: Terapia génica para la hormona tímica timulina en modelos de Timodeficienca e inflamacuión cerebral; Monto: $ 279.200.-

2004-2007 Subsidio trienal PICT03-13588,otorgado por la Agencia Nacional de Promoción Científica y Tecnológica. Tema: Terapia génica en el sistema neuroendócrino senil; Monto: $ 209.----2006 Subsidio trienal PICT02-10663, otorgado por la Agencia Nacional de Promoción Científica y Tecnológica. Tema: Terapia génica para la hormaona tímica timulina en ratones congénitamente atímicos y ratas senescentes;. Monto: $ 201.999

2003-2005 Subsidio de funcionamiento PIP00-02046, otorgado por el CONICET
Monto: $ 24.000

2000-2003 Subsidios automáticos, recibidos en carácter de director, para 2 proyectos de investigación, otorgados por la Universidad Nacional de La Plata en el marco del programa de incentivos a la investigación universitaria. Monto total aproximado: $ 800

2001 Subsidio de funcionamiento PIP, Nro.4081/96 Res.# 1652/00 (3er cuota), otorgado por el CONICET Monto: $ 8.730

1999-2002 Subsidio trienal PICT98, otorgado por la Agencia Nacional de Promoción Científica y Tecnológica.
Monto: $ 148.300

1998 Subsidio de equipamiento PIP, Res.Nro.121/98 otorgado por el CONICET Monto: $5.065

1998 Subsidio de funcionamiento PIP, Res.Nro.406/98 otorgado por el CONICET Monto: $10.200

1997 Subsidio de funcionamiento PICT 0144, otorgado por el Fondo Nacional de Ciencia y Tecnología, SECyT; monto U$S 10.200.

1995 Subsidio para equipamiento otorgado por Fundación Antorchas. Monto: US$ 18.000

1995-2000 Subsidios automáticos, recibidos en carácter de director, para 4 proyectos de investigación, otorgados por la Universidad Nacional de La Plata en el marco del programa de incentivos a la investigación universitaria. Monto total aproximado: $ 3.500

1992-1994 PID legajo# ---(CONICET) Monto aprox. $16.000.



PAPERS


1.- "Histones and related nuclear preparations stimulate prolactin release in vitro" O.A. Brown, Y.E. Sosa, R.G. Goya. Medical Science Research, 21: 799-780 (1993). USA

2.- "Thymic hormones as mediators of the immunogonadotropha integration" O.A. Brown, Y.E. Sosa, R.G. Goya. Latin-American proceedings of Clinical Biochemistry 28: 203-209 (1994). ARG

3.- "In vitro studies on the thymus - pituitary axis in young and old rats" R.G. Goya, Y.E. Sosa, O.A. Brown, M. Dardenne. Annals of the New York Academy of Sciences 741: 108-114 (1994). USA

4.- "Hormonal modulation of antioxidant enzyme activities in young and old rats" A.D. Bolzan, O.A. Brown, R.G. Goya, M.S. Bianchi. Experimental Gerontology 30: 169-175 (1995). UK

5.- " The thymic-neuroendocrine axis and it changes during aging" R.G. Goya, Y.E. Sosa, O.A. Brown, K. Golik. International Journal of Thymology 3(5): 278-281 (1995). ALEMANIA

6.- "Corticotropin-releasing hormone receptor type 1: generation and characterization of polyclonal antipeptide antibodies and their localization in pituitary cells and cortical neurones in vitro " M.G. Castro, E. Morrison, M.J. Perone, O.A. Brown, C.A. Murray, I. Ahmed, A.V. Perkins, G. Europe-Finner, P.R. Lowenstein, E.A. Linton. Journal of Neuroendocrinology 8: 521-531 (1996). UK

7.- "Age-dependent prolactin-releasing activity of nucleoproteins" O.A. Brown, Y.E. Sosa, G.M. Cónsole, R.G. Goya. Mechanisms of Ageing and Development 89: 103-111 (1996). USA

8.- “Uptake of -(L)-iduronidase produced by retrovirally transduced fibroblasts into neuronal and glial cells in vitro. Stewart K., Brown O.A., Morelli A.T., Fairbairn L.J., Lashford L.S., Cooper A., Hatton C.E., Dexter T.M., Castro M.G., Lowenstein P.R. Gene Therapy 4: 63-75 (1997). UK

9.- “Sexual dimorphism in the age changes of the pituitary lactotrophs in rats” Cónsole G.M., Gómez Dumm C.L., Brown O.A., Ferese C., Goya R.G. Mechanisms of Ageing and Development 95: 157-166 (1997). USA

10.-“Gene transfer into enteric neurones of the rat small intestine in organ culture using a replication defective recombinant herpes simplex virus type-1 (HSV-1) vector, but not recombinant adenovirus vectors”. Brown O.A., Santer R.M., Shering A.F., Larregina A.T., Morelli A.E., Southgate T.D., Castro M.G., Lowenstein P.R. Gene Therapy 4: 331-338 (1997). UK

11.- “Effect of the corticotrophin releasing hormone precursor on interleukin-6 release by human mononuclear cells” Salas M.A., Brown O.A., Perone M.J., Castro M.G., Goya R.G. Clinical Immunology and Immunopathology 85: 35-39 (1997). USA

12.-“Thyrotropin-releasing activity of histone H2A, H2B and peptide MB-35” Brown O.A., Sosa Y.E., Goya R.G. Peptides 18: 1315-1319 (1997). USA

13.- “Histones as extracellular messengers: effects on growth hormone secretion” Brown O.A., Sosa Y.E, Goya R.G. Cell Biology International 21: 787-792 (1997). USA

14.- “Gonadotrophin-releasing activity of histones H2A and H2B” Brown O.A., Sosa Y.E., Goya R.G. Cellular and Molecular Life Sciences 54: 288-294 (1998). SUIZA

15.- “Thymulin stimulates prolactin and thyrotropin release in an age-related manner” Brown O.A., Sosa Y.E., Bolognani F., Goya R.G. Mechanisms of Ageing and Development 104: 249-262 (1998). USA

16.- "Procorticotrophin-releasing hormone: endoproteolytic processing and differential release of its derived peptides within AtT20 cells" M. Perone, C.A. Murray, O.A. Brown, S. Gibson., E.A. Linton, A.V. Perkins, P.R. Lowenstein, M.G. Castro. Molecular and Cellular Endocrinology 142:191-202 (1998). USA

17. “Determinaciones Hormonales” Gobello M.G., Brown O.A., Rondero J.R. Analecta Veterinaria 18: 71-81 (1999). ARG

18.- “The thymus-pituitary axis and its changes during aging” Goya R.G., Brown O.A., Bolognani F. NeuroImmunoModulation 6: 137-142 (1999). SUIZA

19.- “Growth hormone-releasing activity of thymulin on pituitary somatotropes is age dependent” Brown O.A., Sosa Y.E., Dardenne M., Pléau J.M., Goya R.G. Neuroendocrinology 69: 20-27 (1999). SUIZA

20.- ¨Studies on the gonadotrpin-releasing activity of thymulin: changes with age¨ Brown O.A., SOSA Y.E., Dardenne M., Pléau J.M., Goya R.G. Jounal of Gerontology (Biological Sciences) 55: B170-176 (2000). USA

21.- “Studies on the prolactin-releasing mechanisms of Histones H2A and B”., Brown O.A., Sosa Y.E., Castro M.G., Goya R.G. Life Sciences 66: 2081-2089 (2000). USA

22.- "Glycolipid anchors are not sufficient to target proteins to the axonal plasma membrane in polarized cortical neurons" O.A. Brown, D. Bain, C. Preston, P. Clissold M.G. Castro, P.R. Lowenstein. Gene Therapy 7: 1947-1953 (2000). UK

23.- “Thymus and aging: potential of gene therapy for restoration of endocrine thymic function in thymus-deficient animal models” Goya R.G., Cónsole G.M., Hereñú C.B., Brown O.A., Rimoldi O. J. Gerontology 48: 325-328 (2002). USA

24.- “Hypophysotropic activity of histone H3 in vivo” Brown O.A., Sosa Y.E., Naumovich D., Hereñú C.B.,Goya R.G. Peptides 24: 671-678 (2003). USA

25.- “Thymulin and the neuroendocrine system” Goya R.G., Brown O.A., Pléau J.M., Dardenne M. Peptides 25: 139-142 (2004). USA

26.- “Potential of gene therapy for the treatment of pituitary tumors” Goya R.G., Sarkar D.K., Brown O.A., Hereñú C.B. Current Gene Therapy 4: 79-87 (2004). USA

27.- “Studies on in vivo gene transfer in pituitary tumors using herpes-derived and adenoviral vectors” Carri N.G., Sosa Y.E., Brown O.A., Albariño C., Romanowski V., Goya R.G. Brain Research Bulletin 65: 17-22 (2005). USA

28. “The neuroendocrine system as a model to evaluate experimental gene therapy” Hereñú C., Brown O.A., Sosa Y.E., Morel G., Reggiani P., Bellini M., Goya R.G. Current Gene Therapy; 6(1): 125-129 (2006). USA
29.- ¨Gene therapy for long-term restoration of circulating thymulin in thymectomized mice and rats¨ Reggiani P., Hereñú C.B., Rimoldi O.J., Brown O.A., Pléau J.M., Dardenne M., Goya R.G. Gene Therapy 13(16): 1214-1221 (2006) . UK
30.-¨Peripheral and mesencephalic transfer of a syntethic gene for the thymic peptide thymulin¨. Morel G.R., Brown O.A., Reggiani P.C., Hereñú C.B., Portiansky E.L., Zuccolilli G.O., Pleau J.M., Dardenne M., Goya R.G. Brain Research Bulletin 69: 647-651 (2006).USA
31.- ¨Gene therapy in the neuroendócrine system¨. Hereñú C.B.,
Morel G.R., Reggiani P., Sosa Y.E., Brown O.A., Goya R.G Frontiers of Hormone Research 35:135-42 (2006). SUIZA
32.- ¨Restoration of reproductive function in immunodeficient mice by the way of the use gene therapy with the gene of the thymulin peptide¨P.C. Reggiani, E.V. Martínes, G.A. Camihort, G. Luna, O.A. Brown, R.G.Goya, G.M.Cónsole Argentine Society of Pharmacology and Terapeutics 1(41): 1-6 (2007).ARG

ABSTRACTS

1."Thymic hormones as mediators of immunogonadotrophic axis integration".
Brown O.A., Sosa Y.E., Goya R.G. XIII Meeting of Latin-American Association of
Investigation on Human Reproduction (ALIRH). Buenos Aires, Argentina. May 23 - 26,
1993.

2."Description of a bioassay of high sensitivity for dosage of substances with
hypofisotrophic activity". Goya R.G., Sosa Y.E., Brown O.A. VI Congress
Argentine of Industrial Pharmacy and Biochemistry. Buenos Aires, Argentina.
May 30 - June 5, 1993.

3."Hormone-releasing activity of thymic epithelial cell products on perifused
pituitary cells from rats of different ages". Goya R.G., Sosa Y.E., Brown O.A., Dardene M. 2nd International Congress of the International Society of Neuroimmunomodulation (ISNIM). Paestum (Salerno), Italy. September 12 - 17,1993.

4."Hypophysiotropic activity of calf thymus histones in vitro: changes with age"
Brown O.A., Sosa Y.E., Goya R.G. 3rd International Congress of the ISNIM. Rio de
Janeiro, Brazil. April 24-28, 1994.

5."Ageing, pituitary hormones and antioxidant enzyme activities in immune and
nonimmune organs of rats" Brown O.A., Bolzan A.D., Bianchi M.S., Goya R.G. 3rd
International Congress of the ISNIM. Rio de Janeiro, Brazil. April 24-28, 1994.

6."Changes in the levels of rat serum DNA during ageing and its relationship
with the neuroendocrine balance" Brown O.A., Golik K.I., Sosa Y.E., Goya
R.G. XXXIX Meeting of the Argentina Society of Clinical Research (SAIC).
Mar del Plata, Argentina. November 25-30, 1994.

7."Gene transfer into pituitary cells using recombinant vectors derived of the type
I Herpes simplex virus". Goya R.G., Lowenstein P.R., Sosa Y.E., Brown O.A., Castro
M.G. XL Meeting of the Argentina Society of Clinical Research (SAIC). Mar del Plata,
Argentina. November 8-12, 1995.

8."Evaluation of different recombinant adenovirus vectors to transfer genes into
normal pituitary cells ". Castro M.G., Lowenstein P.R., Sosa Y.E., Brown O.A., Goya.
R.G XL Meeting of the Argentina Society of Clinical Research (SAIC). Mar del Plata,
Argentina. November 8-12, 1995.

9. "Utilization of recombinant viral vectors to selective gene transfer into pituitary
normal cells". Goya R.G., Lowenstein P.R., Sosa Y.E., Brown O.A., Castro M.G. XL
Meeting of the Argentina Society of Clinical Research (SAIC). Mar del Plata, Argentina.
November 8-12, 1995.

10."Growth hormone-releasing activity of histones H2A and H2B". Brown O.A.,
Sosa Y.E., Goya R.G. 187th Meeting of the Society for Endocrinology with the
Endocrine Section of the RSM. London, UK. November 26-28, 1996.

11.“The effect of proCRH and its cleaved product (1-41 CRH) on interleukin-6
secretion by human mononuclear cells” Salas M.A., Brown O.A., Perone M.J.,
Castro M.G., Goya R.G., González P.H. XLIV Meeting of the Scientific Immunology
Society of Argentina. Córdoba, Argentina. October 24 – 27, 1996.

12.“Studies of the thymus-gonadotrope axis during ageing” Goya R.G., Brown O.A., Sosa Y.E., Carino M.H., Dardenne M. X Congress of Endocrinology and Metabolism Society (SAEM). Buenos Aires, Argentine. October 6-9, 1997.

13.“Studies of the mechanisms involved in the secretion of TSH induced by
histones on rat pituitary cells” Brown O.A., Sosa Y.E., Bolognani F., Goya R.G. X
Congress of Endocrinology and Metabolism Society (SAEM). Buenos Aires, Argentina.
October 6-9, 1997.

14. “Somatotrophic activity of the thymic hormone thymulin” Brown OA, Sosa YE,
Bolognani F, Dardenne M, Goya RG. X Congress of Endocrinology and Metabolism
Society (SAEM). Buenos Aires, Argentina. October 6-9, 1997.

16.“Gene transfer into neuroendocrine system utilizing viral vectors” Brown OA,
Cónsole GM, Hereñú CB, Rimoldi OJ, Sosa YE, Goya RG. Jornada de la Sociedad
Platense de Ciencias Morfológicas, UNLP. La Plata, Argentina 29 de May 2002.

15. “In vivo gene transfer into rat pituitary prolactinomas using viral vectors”
Goya RG, Hereñú CB, Rimoldi OJ, Carri NG, Brown OA. Simposioum of Gene
Therapy in Latinoamérica: from the bench to the clinics. Fundación Leloir. Buenos
Aires, Argentina. May 20 – 22, 2002.

16.“Gene transfer in the hypothalamus and hypophysis of rats by means of
herpetic and adenoviral vectors” Hereñú CB, Cónsole GM, Brown OA, Rimoldi OJ,
Sosa YE, Romanowski V, Goya RG. XXXIV Reunion Anual of the Argentina Society
of Experimental Farmacology. Tandil, Argentina. Nobember 24 – 27, 2002.

17.- “Gene transfer in the hypothalamus and hypophysis of rats by means of herpetic and adenoviral vectors” Hereñú CB, Cónsole GM, Brown OA, Rimoldi OJ, Sosa YE, Romanowski V, Goya RG. XXXIV Annual Reunion of the Argentina Society of Experimental Farmacology. Tandil, argentina. Nobember 24 – 27, 2002.

18.- “Construction of a secuence of ADN that codificates for the thymic hormona thymulin” Reggiani P, Rimoldi OJ, Hereñú CB, Sosa YE, Brown OA, Pléau JM, Dardenne M, Goya RG. Congreso Biomédico Conjunto con SAIC. Mar del Plata, Argentina. November 16-20, 2004.

19.¨Gene therapy in thymectomized rodents using an adenoviral vector expressing a synthetic gene for thymulin¨ Reggiani PC, Hereñú CB,, Rimoldi OJ, Brown OA, Pléau J-M, Dardenne M, Goya RG. 6th Meeting of the Society for NeuroImmunoModulation, Athens, 25-28 September 2005 .

20.- “¨Long term brain expresion of a synthetic gene encoding the anti-inflammatory peptide thymulin”Morel GR, Brown OA, Sosa YE, Hereñú CB, Portiansky EL, zuccolilli GO, Goya RG. Taller de neurosciencia. 8-13 Abril . Huerta Grande, Córdoba, Argentina 2006.


FELLOWSHIPS

1983 Undergraduate Fellowship from UNLP, La Plata, Argentine.

1985 Undergraduate Fellowship from Faculty of Exact Sciences,UNLP, La Plata,
Argentine.

1986 Undergraduate Fellowship from UNLP, La Plata, Argentine.

1991 Hospital Residency in the Interzonal Hospital of Acute Diseases of La Plata
from Buenos Aires Health Ministry, La Plata, Argentine.

1993 Training Fellowship from Scientific Research Committee of Buenos Aires (CIC),
La Plata, Argentine.

1994 Training Fellowship from National Research Council of Argentine (CONICET),
Buenos Aires, Argentine.

1995 Training Fellowship from British Council - Antorchas Foundation. From
January to July. Laboratory of Molecular and Cellular Neurobiology, Physiology
Unit, University of Wales, College of Cardiff, Cardiff, UK.

1996 Advanced Training Fellowship from National Research Council of Argentine
(CONICET), Buenos Aires, Argentine. Scored first in the merit order by the
Medical Sciences Committee of CONICET which is responsible of evaluate the
merits of each prospective candidate, from Argentine or abroad, postulated for a CONICET’s Fellowship in the Medical Science field.


HUMAN RESOURSES FORMATION

1997-1998 SUPERVISSOR of Veterinary Medical, Cristina gobello in the postgraduate course: Immunomethods in endocrinology with 140 h totals of theory and practice.

WORKS

1989 Substitute Clinical Technician. Haematology Laboratory, Private Institute
of Clinical Medicine and Surgery. City Bell, Argentine.

1989 - 1991 Laboratory Technician. Interzonal Hospital of Acute Diseases (HIGA)
"José de San Martín". La Plata, Argentina.

1992-1993 Research Assistant. Depertment of Biological Sciences, University of
Arkansas Fayetteville, Arkansas, USA. Grant # 0402-01450-21-0000 US/NSF/DCB-
92-96030/KAPLAN.

AHORA ESTOY ESCRIBIENDO UN PEDIDO DE SUBSIDIO PARE EL FP7 PROGAM DE LA UNION EUROPEA CON UN EGIPCIO

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